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Featured article of the month archive - 2021

Welcome to the CannaQAwiki 2021 archive for the Featured Article of the Month.

Featured article of the month: June 2021:

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"Development of a gas-chromatographic method for simultaneous determination of cannabinoids and terpenes in hemp"

An original gas-chromatographic method has been developed for simultaneous determination of major terpenes and cannabinoids in plant samples and their extracts. The main issues to be addressed were not only the large differences in polarity and volatility between both groups of analytes, but also the need for an exhaustive decarboxylation of cannabinoid acidic forms. Sample preparation was minimized by avoiding any analyte derivatization. Acetone was found to be the most appropriate extraction solvent. Successful chromatographic separation was achieved by using a medium-polarity column. Limits of detection ranged from 120 to 260 ng/mL for terpenes and from 660 to 860 ng/mL for cannabinoids. (Full article...)

Featured article of the month: May 2021:

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"Cannabinoid, terpene, and heavy metal analysis of 29 over-the-counter commercial veterinary hemp supplements"

The use of veterinary low-tetrahydrocannabinol (THC) Cannabis sativa (i.e., hemp) products has increased in popularity for a variety of pet ailments. Low-THC Cannabis sativa is federally legal for sale and distribution in the United States, and the rise in internet commerce has provided access to interested consumers, with minimal quality control. We performed an internet word search of “hemp extract and dog” or “CBD product and dog” and analyzed 29 products that were using low-THC Cannabis sativa extracts in their production of supplements. All products were tested for major cannabinoids, including ∆9-tetrahydrocannabinol (THC), cannabidiol (CBD), cannabigerol (CBG), and other minor cannabinoids, as well as their respective carboxylic acid derivatives tetrahydrocannabinolic acid (THCA), cannabidiolic acid (CBDA), and cannabigerolic acid (CBGA) using an ISO/IEC 17025-certified laboratory.(Full article...)

Featured article of the month: March 2021:

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"Methods for quantification of cannabinoids: A narrative review"

Around 144 cannabinoids have been identified in the Cannabis plant; among them tetrahydrocannabinol (THC) and cannabidiol (CBD) are the most prominent ones. Because of the legal restrictions on cannabis in many countries, it is difficult to obtain standards to use in research; nonetheless, it is important to develop a cannabinoid quantification technique, with practical pharmaceutical applications for quality control of future therapeutic cannabinoids. To find relevant articles for this narrative review paper, a combination of keywords such as "medicinal cannabis," "analytical," "quantification," and "cannabinoids" were searched for in PubMed, EMBASE, MEDLINE, Google Scholar, and Cochrane Library (Wiley) databases. (Full article...)

Featured article of the month: February 2021:


"Analysis of phenolic compounds in commercial Cannabis sativa L. inflorescences using UHPLC-Q-Orbitrap HRMS"

Industrial hemp (Cannabis sativa L., family Cannabaceae) contains a vast number of relevant bioactive organic compounds, namely polyphenols, including flavonoids, phenolic acids, phenol amides, and lignanamides, which are well known for their therapeutic properties. Nowadays, many polyphenol-containing products made from herbal extracts are marketed, claiming to have health-promoting effects. In this context, industrial hemp inflorescences may represent an innovative source of bioactive compounds to be used in nutraceutical formulations. The aim of this work was to provide a comprehensive analysis of the polyphenolic fraction contained in polar extracts of four different commercial cultivars—Kompolti, Tiborszallasi, Antal, and Selected Carmagnola (CS)—of hemp inflorescence ... (Full article...)

Featured article of the month: January 2021:

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"Analysis of cannabidiol, delta-9-tetrahydrocannabinol, and their acids in CBD/hemp oil products"

Hemp products are readily available and are aggressively marketed for their health and medicinal benefits. Most consumers of these products are interested because of their cannabidiol (CBD) content, which has taken the natural products industry by storm. The CBD and delta-9-tetrahydrocannabinol (delta-9-THC) concentrations in these products are often absent, and even where labeled, the accuracy of the label amounts is often questionable. In order to gain a better understanding of the CBD content, fifty hemp products were analyzed by gas chromatography coupled with mass spectrometry (GC-MS) for CBD, delta-9-THC, tetrahydrocannabinolic acid (delta-9-THCAA), and cannabidiolic acid (CBDA). Delta-9-THCAA and CBDA are the natural precursors of delta-9-THC and CBD in the plant material. (Full article...)