Difference between revisions of "Template:Past, Present, and Future of Cannabis Laboratory Testing and Regulation in the United States/Cannabis testing instruments, software, and equipment/Vendors: 0 through F"
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A variety of techniques are used to investigate the constituents of [[cannabis]] and their concentrations. From [[gas chromatography]] to make determinations about [[terpene]]s in a [[Sample (material)|sample]] to [[Real-time polymerase chain reaction|quantitative polymerase chain reaction]] (qPCR) techniques to identify [[mycotoxin]]s and [[microorganism]]s, these differing techniques require a wide variety of [[laboratory]] tools. The most common among cannabis testing instruments are [[chromatography]] and [[spectroscopy]] equipment, often combined together for a more complete analysis. However, this equipment can be expensive, sometimes prohibitively expensive. Initial investments may range anywhere from $75,000 up to $600,000 or more, depending on what sort of testing is being performed in the lab.<ref name="SchroverIndustry16">{{cite web |url=https://mjbizmagazine.com/industry-snapshot-testing-labs/ |title=Industry Snapshot: Testing Labs |author=Schrover, J. |work=Marijuana Business Magazine |date=January 2016 |accessdate= | A variety of techniques are used to investigate the constituents of [[cannabis]] and their concentrations. From [[gas chromatography]] to make determinations about [[terpene]]s in a [[Sample (material)|sample]] to [[Real-time polymerase chain reaction|quantitative polymerase chain reaction]] (qPCR) techniques to identify [[mycotoxin]]s and [[microorganism]]s, these differing techniques require a wide variety of [[laboratory]] tools. The most common among cannabis testing instruments are [[chromatography]] and [[spectroscopy]] equipment, often combined together for a more complete analysis. However, this equipment can be expensive, sometimes prohibitively expensive. Initial investments may range anywhere from $75,000 up to $600,000 or more, depending on what sort of testing is being performed in the lab.<ref name="SchroverIndustry16">{{cite web |url=https://mjbizmagazine.com/industry-snapshot-testing-labs/ |title=Industry Snapshot: Testing Labs |author=Schrover, J. |work=Marijuana Business Magazine |date=January 2016 |accessdate=08 July 2022}}</ref><ref name="CliffordCanna18">{{cite web |url=https://www.news-medical.net/news/20180205/Cannabis-Quality-and-Contamination-Testing.aspx |title=Cannabis Quality and Contamination Testing |author=Clifford, B. |work=News Medical Life Sciences |date=05 February 2018 |accessdate=08 July 2022}}</ref><ref name="BorchardtCannabis17">{{cite web |url=https://www.forbes.com/sites/debraborchardt/2017/04/05/cannabis-lab-testing-is-the-industrys-dirty-little-secret/ |title=Cannabis Lab Testing Is The Industry's Dirty Little Secret |author=Borchardt, D. |work=Forbes |date=05 April 2017 |accessdate=08 July 2022}}</ref> As such, newly founded labs or labs looking to expand their analytic offerings to cannabis testing may also consider the purchase of previously owned equipment to save on initial start-up costs. | ||
What follows is a list of vendors known to offer new and/or used instruments, software, and equipment commonly used in cannabis testing laboratories, with links to either the instruments marketed for cannabis testing or a landing page to begin a search. This is by no means a complete list but a representative example of the vendors marketing to the cannabis testing industry. | What follows is a list of vendors known to offer new and/or used instruments, software, and equipment commonly used in cannabis testing laboratories, with links to either the instruments marketed for cannabis testing or a landing page to begin a search. This is by no means a complete list but a representative example of the vendors marketing to the cannabis testing industry. | ||
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==4.1 Vendors: 0 through F== | ==4.1 Vendors: 0 through F== | ||
===4.1.1 AB Sciex Pte. Ltd.=== | ===4.1.1 AB Sciex Pte. Ltd.=== | ||
'''Main landing page for cannabis testing''': https://sciex.com | '''Main landing page for cannabis testing''': https://sciex.com/applications/food-and-beverage-testing/cannabis-testing | ||
Commonly known as Sciex, AB Sciex Pte. Ltd. develops "solutions in mass spectrometry and capillary electrophoresis."<ref name="SciexAbout">{{cite web |url=https://sciex.com | Commonly known as Sciex, AB Sciex Pte. Ltd. develops "solutions in mass spectrometry and capillary electrophoresis."<ref name="SciexAbout">{{cite web |url=https://sciex.com/about-us |title=About Us |publisher=AB Sciex Pte. Ltd |accessdate=08 July 2022}}</ref> The company markets some of its solutions for cannabis lab testing, including<ref name="SciexCanna">{{cite web |url=https://sciex.com/applications/food-and-beverage-testing/cannabis-testing |title=Cannabis and hemp testing analytical solutions & technologies |publisher=AB Sciex Pte. Ltd |accessdate=08 July 2022}}</ref>: | ||
* potency testing | * potency testing | ||
| Line 17: | Line 17: | ||
'''Triple Quad systems''' | '''Triple Quad systems''' | ||
Sciex offers | Sciex offers five different Triple Quad systems for tandem mass spectrometry paired with liquid chromatography (LC-MS/MS): the 7500, 6500+, 5500+, 4500, and 3500. The company claims that with these systems "scientists can acquire multiple reaction monitoring (MRM), precursor, neutral loss, and product ion scans to develop powerful methods for complex matrices, all while maintaining reproducibility and robustness."<ref name="SciexTQ">{{cite web |url=https://sciex.com/products/mass-spectrometers/triple-quad-systems |title=SCIEX Triple Quad LC-MS/MS Systems |publisher=AB Sciex Pte. Ltd |accessdate=08 July 2022}}</ref> | ||
* [https://sciex.com | * [https://sciex.com/products/mass-spectrometers/triple-quad-systems/triple-quad-7500-system 7500] | ||
* [https://sciex.com | * [https://sciex.com/products/mass-spectrometers/triple-quad-systems/triple-quad-6500plus-system 6500+] | ||
* [https://sciex.com | * [https://sciex.com/products/mass-spectrometers/triple-quad-systems/triple-quad-5500-lc-ms-ms-system-qtrap-ready 5500+] | ||
* [https://sciex.com | * [https://sciex.com/products/mass-spectrometers/triple-quad-systems/triple-quad-4500-system 4500] | ||
* [https://sciex.com | * [https://sciex.com/products/mass-spectrometers/triple-quad-systems/triple-quad-3500-system 3500] | ||
'''QTRAP systems''' | '''QTRAP systems''' | ||
Sciex also offers | Sciex also offers four different Triple Quad Linear Ion Trap (QTRAP) or QTRAP-ready systems for LC-MS/MS: the 7500, 6500+, 5500+, and 4500. The company states that these are similar to the Triple Quad systems "but with enhanced scan functions to enable simultaneous quantitation and confirmation."<ref name="SciexQTRAP">{{cite web |url=https://sciex.com/products/mass-spectrometers/qtrap-systems |title=QTRAP LC-MS/MS Systems |publisher=AB Sciex Pte. Ltd |accessdate=08 July 2022}}</ref> | ||
* [https://sciex.com/ | * [https://sciex.com/products/mass-spectrometers/triple-quad-systems/triple-quad-7500-system 7500] (QTRAP-ready) | ||
* [https://sciex.com | * [https://sciex.com/products/mass-spectrometers/qtrap-systems/qtrap-6500plus-system QTRAP 6500+] | ||
* [https://sciex.com | * [https://sciex.com/products/mass-spectrometers/triple-quad-systems/triple-quad-5500-lc-ms-ms-system-qtrap-ready QTRAP 5500+] (QTRAP-ready) | ||
* [https://sciex.com/products/mass-spectrometers/qtrap-systems/qtrap-4500-system QTRAP 4500] | |||
'''vMethod for Cannabis''' | '''vMethod for Cannabis''' | ||
Sciex also offers a "[https://sciex.com | Sciex also offers a "[https://sciex.com/products/methods/vmethod-application-for-quantitation-of-pesticide-residues-and-cannabinoids-in-cannabis-matrices-10 vMethod]," a quantitation method for pesticide and cannabinoid analysis, that works on many of their LC-MS/MS systems.<ref name="SciexVMethodCann">{{cite web |url=https://sciex.com/products/methods/vmethod-application-for-quantitation-of-pesticide-residues-and-cannabinoids-in-cannabis-matrices-10 |title=vMethod Application for Quantitation of Pesticide Residues and Cannabinoids in Cannabis Matrices 1.0 |publisher=AB Sciex Pte. Ltd |accessdate=08 July 2022}}</ref> | ||
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'''Main landing page for cannabis testing''': https://www.agilent.com/en/solutions/cannabis-hemp-testing | '''Main landing page for cannabis testing''': https://www.agilent.com/en/solutions/cannabis-hemp-testing | ||
Agilent Technologies, Inc. is an instrument and software development company for the life sciences, diagnostics, and applied chemical industries. The company offers a variety of chromatography and spectrometry instruments (using a wide array of techniques) and software for the cannabis testing industry, including<ref name="AgilentCanna">{{cite web |url=https://www.agilent.com/en/solutions/cannabis-hemp-testing |title=Cannabis & Hemp Testing |publisher=Agilent Technologies, Inc |accessdate= | Agilent Technologies, Inc. is an instrument and software development company for the life sciences, diagnostics, and applied chemical industries. The company offers a variety of chromatography and spectrometry instruments (using a wide array of techniques) and software for the cannabis testing industry, including<ref name="AgilentCanna">{{cite web |url=https://www.agilent.com/en/solutions/cannabis-hemp-testing |title=Cannabis & Hemp Testing |publisher=Agilent Technologies, Inc |accessdate=08 July 2022}}</ref>: | ||
* potency and efficacy testing | * potency and efficacy testing | ||
| Line 56: | Line 57: | ||
'''Potency and efficacy testing''' | '''Potency and efficacy testing''' | ||
* [https://www.agilent.com/en/product/liquid-chromatography/hplc-systems/analytical-hplc-systems/ | * [https://www.agilent.com/en/product/liquid-chromatography/hplc-systems/analytical-hplc-systems/1220-infinity-ii-lc-system 1220 Infinity II LC System]: an HPLC system | ||
* [https://www.agilent.com/en/product/liquid-chromatography/hplc-systems/analytical-hplc-systems/ | * [https://www.agilent.com/en/product/liquid-chromatography/hplc-systems/analytical-hplc-systems/1260-infinity-ii-lc-system 1260 Infinity II LC System]: an HPLC system with the ability to handle entry-level ultra-high performance liquid chromatography (UHPLC) | ||
* [https://www.agilent.com/en/product/liquid-chromatography-mass-spectrometry-lc-ms/lc-ms-instruments/single-quadrupole-lc-ms/lc-msd-iq InfinityLab LC/MSD iQ]: a liquid chromatography-mass selective detector (LC/MSD) system | |||
* [https://www.agilent.com/en/product/ | * [https://www.agilent.com/en/products/ftir/ftir-benchtop-systems/cary-630-ftir-spectrometer Cary 630 FT-IR Spectrometer]: a Fourier-transform infrared spectrometer | ||
* [https://www.agilent.com/en/ | |||
'''Heavy metals testing''' | '''Heavy metals testing''' | ||
Revision as of 18:29, 9 July 2022
A variety of techniques are used to investigate the constituents of cannabis and their concentrations. From gas chromatography to make determinations about terpenes in a sample to quantitative polymerase chain reaction (qPCR) techniques to identify mycotoxins and microorganisms, these differing techniques require a wide variety of laboratory tools. The most common among cannabis testing instruments are chromatography and spectroscopy equipment, often combined together for a more complete analysis. However, this equipment can be expensive, sometimes prohibitively expensive. Initial investments may range anywhere from $75,000 up to $600,000 or more, depending on what sort of testing is being performed in the lab.[1][2][3] As such, newly founded labs or labs looking to expand their analytic offerings to cannabis testing may also consider the purchase of previously owned equipment to save on initial start-up costs.
What follows is a list of vendors known to offer new and/or used instruments, software, and equipment commonly used in cannabis testing laboratories, with links to either the instruments marketed for cannabis testing or a landing page to begin a search. This is by no means a complete list but a representative example of the vendors marketing to the cannabis testing industry.
4.1 Vendors: 0 through F
4.1.1 AB Sciex Pte. Ltd.
Main landing page for cannabis testing: https://sciex.com/applications/food-and-beverage-testing/cannabis-testing
Commonly known as Sciex, AB Sciex Pte. Ltd. develops "solutions in mass spectrometry and capillary electrophoresis."[4] The company markets some of its solutions for cannabis lab testing, including[5]:
- potency testing
- mycotoxin testing
- pesticide testing
- terpene testing
Instruments and methods
Triple Quad systems
Sciex offers five different Triple Quad systems for tandem mass spectrometry paired with liquid chromatography (LC-MS/MS): the 7500, 6500+, 5500+, 4500, and 3500. The company claims that with these systems "scientists can acquire multiple reaction monitoring (MRM), precursor, neutral loss, and product ion scans to develop powerful methods for complex matrices, all while maintaining reproducibility and robustness."[6]
QTRAP systems
Sciex also offers four different Triple Quad Linear Ion Trap (QTRAP) or QTRAP-ready systems for LC-MS/MS: the 7500, 6500+, 5500+, and 4500. The company states that these are similar to the Triple Quad systems "but with enhanced scan functions to enable simultaneous quantitation and confirmation."[7]
- 7500 (QTRAP-ready)
- QTRAP 6500+
- QTRAP 5500+ (QTRAP-ready)
- QTRAP 4500
vMethod for Cannabis
Sciex also offers a "vMethod," a quantitation method for pesticide and cannabinoid analysis, that works on many of their LC-MS/MS systems.[8]
4.1.2 Agilent Technologies, Inc.
Main landing page for cannabis testing: https://www.agilent.com/en/solutions/cannabis-hemp-testing
Agilent Technologies, Inc. is an instrument and software development company for the life sciences, diagnostics, and applied chemical industries. The company offers a variety of chromatography and spectrometry instruments (using a wide array of techniques) and software for the cannabis testing industry, including[9]:
- potency and efficacy testing
- heavy metals testing
- microbial testing
- mycotoxin testing
- pesticide testing
- residual solvents testing
- terpene testing
Instruments and methods
The company suggests instrument options based on what type of testing will occur.[9]
Potency and efficacy testing
- 1220 Infinity II LC System: an HPLC system
- 1260 Infinity II LC System: an HPLC system with the ability to handle entry-level ultra-high performance liquid chromatography (UHPLC)
- InfinityLab LC/MSD iQ: a liquid chromatography-mass selective detector (LC/MSD) system
- Cary 630 FT-IR Spectrometer: a Fourier-transform infrared spectrometer
Heavy metals testing
- 5110 ICP-OES Instrument: an inductively coupled plasma optical emission spectrometry (ICP-OES) instrument with synchronous radial and axial measurement
- 7800 ICP-MS: an inductively coupled plasma mass spectrometry (ICP-MS) instrument
- 7900 ICP-MS: an inductively coupled plasma mass spectrometry (ICP-MS) instrument with higher matrix tolerance, wider dynamic range, and better signal-to-noise ratio
- 8900 Triple Quadrupole ICP-MS: an inductively coupled plasma normal and tandem mass spectroscopy instrument with triple quadrupole
Pesticide and mycotoxin testing
- Triple Quadrupole LC/MS: liquid chromatography normal and tandem mass spectrometry instruments, with two variations (-70B and -95C)
- 6500 Series Accurate-Mass Quadrupole Time-of-Flight (Q-TOF) LC/MS: quadrupole time-of-flight liquid chromatography-mass spectrometry instruments, with six variations (6530, -45, -45XT, -46, -50, and -60)
- 7000D Triple Quadrupole GC/MS: a gas chromatography normal and tandem mass spectroscopy instrument with triple quadrupole and dynamic MRM
- Intuvo 9000 GC System: an ultra-fast gas chromatography system that works with with 5977B, 7000D, and 7010B mass spectrometers
- GC/MS/MS Pesticides Analyzer: a gas chromatography tandem mass spectroscopy instrument with triple quadrupole
Residual solvents testing
- 8890 Series GC with 7697A Headspace Sampler and Flame Ionization Detector: a gas chromatography instrument combined with the 7697A Headspace Sampler and compatible flame ionization detector
- Intuvo 9000 GC System: an ultra-fast gas chromatography system that works with with 5977B, 7000D, and 7010B mass spectrometers
Terpene testing
- 1260 Infinity II Diode Array Detector HS: a liquid chromatography high-sensitivity diode array detector
- 1260 Infinity II Diode Array Detector WR: a liquid chromatography wide-range diode array detector
- 8890 Series GC with 7697A Headspace Sampler and Flame Ionization Detector: a gas chromatography instrument combined with the 7697A Headspace Sampler and compatible flame ionization detector
- Intuvo 9000 GC System: an ultra-fast gas chromatography system that works with with 5977B, 7000D, and 7010B mass spectrometers
Software
- ICP Expert Software for ICP-OES: inductively coupled plasma optical emission spectrometry (ICP-OES) software for data analysis
- MassHunter: mass spectrometry software for instrument control, monitoring, and data analysis
- MicroLab: fourier-transform infrared spectroscopy software for quantitative method development, calibrations, and data analysis
4.1.3 Alpha-CAT Lab s.r.o.
Main landing page for cannabis production: https://www.alpha-cat.org/resources/how-it-works/
alpha-CAT Lab s.r.o. is a cannabis testing and equipment manufacturing business based in Prague, Czech Republic. The company not only runs cannabis testing laboratories in Europe but also develops the alpha-CAT cannabinoid analysis tool "which combines the simple analytical technique of thin-layer chromatography (TLC) with specific thin-layers and developing fluid."[10] Consult the website for more information.
4.1.4 BÜCHI Labortechnik AG
Main landing page for cannabis production: https://www.buchi.com/en/cannabis-application-booklet
BÜCHI Labortechnik AG is laboratory technology development company for research and development, quality control, and production operations globally. The company offers a variety of instruments and equipment for cannabis production workflow, including[11]:
- post-chromatography and post-extraction solvent concentration
- preparative chromatography for purification of cannabinoids
- microencapsulation of CBD into gelatin beads/soft oil core capsules
- formulation of CBD into an inhalable/edible dry powder
See the Theory & Applications booklet (main landing page) for more details on how to integrate the equipment for each activity.
Instruments and methods
The company suggests instrument options based on what type of production activity will occur.[11]
Post-chromatography and post-extraction solvent concentration
- Rotavapor R-220 Pro: an industrial evaporator with programmable methods, automatic distillation, and remote monitoring options
- F-325 Recirculating Chiller
- V-600 Vacuum Pump
Preparative chromatography for purification of cannabinoids
- Pure Chromatography Systems: flash column chromatography for separations and flash purification; more advanced than the Sepacore
- Sepacore Flash Systems X10/X50: flash column chromatography for separations and flash purification
- C-601 Pump
- C-650 ELS Detector: an evaporative light scattering detector for any mobile phase or gradient
Microencapsulation of CBD into gelatin beads/soft oil core capsules
- Encapsulator B-390
- Encapsulator B-395 Pro
- Rotavapor R-300: a rotary evaporator
- Interface I-300 Pro
- F-305 Recirculating Chiller
- V-300 Vacuum Pump
Formulation of CBD into an inhalable/edible dry powder
4.1.5 CEM Corporation
Main landing page for cannabis testing: https://cem.com/en/cannabis
CEM Corporation is laboratory instrumentation and method design and development company, with a focus on compositional analysis of food and other samples, as well acid digestion and chemical synthesis. CEM specifically offers two different instruments for cannabis testing and analysis labs, including instruments for the[12]:
- extraction for potency, pesticide, terpene, and mycotoxin testing
- microwave digestion of oils, edibles, and plant material (before, e.g., inductively coupled plasma mass spectroscopy)
Instruments and methods
- EDGE: an automated instrument for energized dispersive extraction and dispersive solid-phase extraction (dSPE)
- MARS 6: a microwave digestion system with hundreds of preprogrammed methods
4.1.6 Conquer Scientific Service, Inc.
Main landing page for cannabis testing: https://conquerscientific.com/cannabis-testing/
Conquer Scientific Service, Inc. is a distributor of gently used laboratory testing equipment, including for the cannabis testing industry. Such instruments include a wide variety of chromatography and spectrometry devices, along with other essential supporting laboratory equipment like moisture analyzers. Conquer also offers repair services, including a same-day replacement program for Southern California customers.
4.1.7 Emerald Scientific, LLC
Main landing page for cannabis testing: https://emeraldscientific.com/
Emerald Scientific, LLC calls their business "[t]he first and only company 100% dedicated to distributing scientific supplies and equipment to the cannabis industry."[13] The company lists a wide variety of instruments, equipment, and consumables for cannabis testing, production, and extraction laboratories. Emerald acts as a distributor of other products, and thus the inventory may change. Examples of inventory include:
- sample preparation supplies
- solvents
- mass spectrometry columns
- heating mantles
- chillers and circulators
- vacuum pumps and tubing
- reference standards
- culture media
- safety equipment
Consult the Emerald website to see all they offer.
4.1.8 Fritsch GmbH
Main landing page for cannabis testing: https://www.fritsch-international.com/sample-preparation/applications-solutions/ (select "Cannabis" from Industry option)
Fritsch GmbH manufactures sample preparation and particle sizing equipment for laboratories. The company lists one instrument specifically for the cannabis industry.
Instruments and methods
- Universal Cutting Mill PULVERISETTE 19: a cutting mill "to finely mill cannabis plant material in preparation for SFE processes," noting that "[t]he efficient and precise reduction in particle size optimizes oil output and formulation."[14]
- ↑ Schrover, J. (January 2016). "Industry Snapshot: Testing Labs". Marijuana Business Magazine. https://mjbizmagazine.com/industry-snapshot-testing-labs/. Retrieved 08 July 2022.
- ↑ Clifford, B. (5 February 2018). "Cannabis Quality and Contamination Testing". News Medical Life Sciences. https://www.news-medical.net/news/20180205/Cannabis-Quality-and-Contamination-Testing.aspx. Retrieved 08 July 2022.
- ↑ Borchardt, D. (5 April 2017). "Cannabis Lab Testing Is The Industry's Dirty Little Secret". Forbes. https://www.forbes.com/sites/debraborchardt/2017/04/05/cannabis-lab-testing-is-the-industrys-dirty-little-secret/. Retrieved 08 July 2022.
- ↑ "About Us". AB Sciex Pte. Ltd. https://sciex.com/about-us. Retrieved 08 July 2022.
- ↑ "Cannabis and hemp testing analytical solutions & technologies". AB Sciex Pte. Ltd. https://sciex.com/applications/food-and-beverage-testing/cannabis-testing. Retrieved 08 July 2022.
- ↑ "SCIEX Triple Quad LC-MS/MS Systems". AB Sciex Pte. Ltd. https://sciex.com/products/mass-spectrometers/triple-quad-systems. Retrieved 08 July 2022.
- ↑ "QTRAP LC-MS/MS Systems". AB Sciex Pte. Ltd. https://sciex.com/products/mass-spectrometers/qtrap-systems. Retrieved 08 July 2022.
- ↑ "vMethod Application for Quantitation of Pesticide Residues and Cannabinoids in Cannabis Matrices 1.0". AB Sciex Pte. Ltd. https://sciex.com/products/methods/vmethod-application-for-quantitation-of-pesticide-residues-and-cannabinoids-in-cannabis-matrices-10. Retrieved 08 July 2022.
- ↑ 9.0 9.1 "Cannabis & Hemp Testing". Agilent Technologies, Inc. https://www.agilent.com/en/solutions/cannabis-hemp-testing. Retrieved 08 July 2022.
- ↑ "How it works". Alpha-CAT Lab s.r.o. https://www.alpha-cat.org/resources/how-it-works/. Retrieved 09 January 2021.
- ↑ 11.0 11.1 "Cannabis Booklet: Theory & Applications" (PDF). BÜCHI Labortechnik AG. https://static1.buchi.com/sites/default/files/content-page/downloads/Application_Booklet_Cannabis_.pdf. Retrieved 09 January 2021.
- ↑ "Cannabis Analysis". CEM Corporation. https://cem.com/en/cannabis. Retrieved 09 January 2021.
- ↑ "Emerald Scientific". Emerald Scientific, LLC. https://emeraldscientific.com/. Retrieved 21 November 2018.
- ↑ "CANNABIS PLANT MATERIAL PREPARATION FOR EFFICIENT EXTRACTION". Fritsch GmbH. https://www.fritsch-international.com/sample-preparation/applications-solutions/details/solution/cannabis-plant-material-preparation-for-efficient-extraction/. Retrieved 09 January 2021.
