Journal:The impact of extraction protocol on the chemical profile of cannabis extracts from a single cultivar
| Full article title | The impact of extraction protocol on the chemical profile of cannabis extracts from a single cultivar |
|---|---|
| Journal | Scientific Reports |
| Author(s) | Bowen, Janina K.; Chaparro, Jacqueline M.; McCorkle, Alexander M.; Palumbo, Edward; Prenni, Jessica E. |
| Author affiliation(s) | Colorado State University, Charlotte’s Web Inc. |
| Primary contact | jprenni at colostate dot edu |
| Year published | 2021 |
| Volume and issue | 11 |
| Article # | 21801 |
| DOI | 10.1038/s41598-021-01378-0 |
| ISSN | 2045-2322 |
| Distribution license | Creative Commons Attribution 4.0 International |
| Website | https://www.nature.com/articles/s41598-021-01378-0 |
| Download | https://www.nature.com/articles/s41598-021-01378-0.pdf (PDF) |
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This article should be considered a work in progress and incomplete. Consider this article incomplete until this notice is removed. |
Abstract
The last two decades have seen a dramatic shift in cannabis legislation around the world. Cannabis products are now widely available, and commercial production and use of phytocannabinoid products is rapidly growing. However, this growth is outpacing the research needed to elucidate the therapeutic efficacy of the myriad of chemical compounds found primarily in the flower of the female Cannabis plant. This lack of research and corresponding regulation has resulted in processing methods, products, and terminology that are variable and confusing for consumers. Importantly, the impact of processing methods on the resulting chemical profile of full spectrum cannabis extracts is not well understood. As a first step in addressing this knowledge gap, we have utilized a combination of analytical approaches to characterize the broad chemical composition of a single cannabis cultivar that was processed using previously optimized and commonly used commercial extraction protocols, including alcoholic solvents and supercritical carbon dioxide. Significant variation in the bioactive chemical profile was observed in the extracts resulting from the different protocols, demonstrating the need for further research regarding the influence of processing on therapeutic efficacy, as well as the importance of labeling in the marketing of multi-component cannabis products.
Keywords: Cannabis, processing methods, extract, cultivar, chemical analysis
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This presentation is faithful to the original, with only a few minor changes to presentation. Some grammar and punctuation was cleaned up to improve readability. In some cases important information was missing from the references, and that information was added.
