Journal:Recent advances in electrochemical sensor technologies for THC detection—A narrative review
| Full article title | Recent advances in electrochemical sensor technologies for THC detection—A narrative review |
|---|---|
| Journal | Journal of Cannabis Research |
| Author(s) | Amini, Kaveh; Sepehrifard, Ali; Valinasabpouri, Ali; Safruk, Jennifer; Angelone, Davide; de Campos Lourenco, Tiago |
| Author affiliation(s) | Selective Lab, Inc. |
| Primary contact | Email: kamini at selectivelab dot com |
| Year published | 2022 |
| Volume and issue | 4 |
| Article # | 12 |
| DOI | 10.1186/s42238-022-00122-3 |
| ISSN | 2522-5782 |
| Distribution license | Creative Commons Attribution 4.0 International |
| Website | https://jcannabisresearch.biomedcentral.com/articles/10.1186/s42238-022-00122-3 |
| Download | https://jcannabisresearch.biomedcentral.com/track/pdf/10.1186/s42238-022-00122-3.pdf (PDF) |
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This article should be considered a work in progress and incomplete. Consider this article incomplete until this notice is removed. |
Abstract
Background: delta-9-tetrahydrocannabinol (Δ9-THC or simply THC) is the main psychoactive component and one of the most important medicinal compounds in cannabis. Whether in human body fluids and breath or in laboratory and field samples, rapid and easy detection of THC is crucial. It provides insights into the impact of THC on the human organism, as well as its medicinal benefits. It also guides cannabis growers in determining different stages of the growth of the plant in the field, and eventually it helps scientists in the laboratory to assure the quality of the products and determine their potency or better understand product development procedures. The significance of fast THC detection in forensic analysis also cannot be overlooked. Electrochemical sensor technologies show promise in fulfilling the need for fast, easy, and low-cost detection of THC.
Method: In this work, we review the recent advances in sensor technologies developed for the purpose of fast and accurate THC detection. Research performed mostly in the past decade, and that detecting THC directly without any derivatization, was the main target of this review. The scope of this narrative review was reports on detecting THC in synthetic samples and plants as well as oral fluid.
Results: Electrochemical sensor technologies are sensitive enough and have the potential for fast, easy, and low-cost detection of THC for roadside testing, THC trending in growing cannabis plants, THC product development, and formulation for medical purposes, etc. They can also provide an alternative for costly chromatography and ppmass spectrometry]]-based methods.
Conclusion: The main challenges facing electrochemical sensors, however, are nonspecific interaction and the interference of compounds and species from the matrix. Special requirement for storing sensors modified with antibodies or proteins is another challenge in this field. Preparing long-lasting and reusable sensors is a field worthy of attention.
Keywords: Δ9-tetrahydrocannabinol, THC, sensor, cannabis, electrochemical detection
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This presentation is faithful to the original, with only a few minor changes to presentation. Some grammar and punctuation was cleaned up to improve readability. In some cases important information was missing from the references, and that information was added.
