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"Development of a gas-chromatographic method for simultaneous determination of cannabinoids and terpenes in hemp"

An original gas-chromatographic method has been developed for simultaneous determination of major terpenes and cannabinoids in plant samples and their extracts. The main issues to be addressed were not only the large differences in polarity and volatility between both groups of analytes, but also the need for an exhaustive decarboxylation of cannabinoid acidic forms. Sample preparation was minimized by avoiding any analyte derivatization. Acetone was found to be the most appropriate extraction solvent. Successful chromatographic separation was achieved by using a medium-polarity column. Limits of detection ranged from 120 to 260 ng/mL for terpenes and from 660 to 860 ng/mL for cannabinoids. (Full article...)

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