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"Methods for quantification of cannabinoids: A narrative review"

Around 144 cannabinoids have been identified in the Cannabis plant; among them tetrahydrocannabinol (THC) and cannabidiol (CBD) are the most prominent ones. Because of the legal restrictions on cannabis in many countries, it is difficult to obtain standards to use in research; nonetheless, it is important to develop a cannabinoid quantification technique, with practical pharmaceutical applications for quality control of future therapeutic cannabinoids. To find relevant articles for this narrative review paper, a combination of keywords such as "medicinal cannabis," "analytical," "quantification," and "cannabinoids" were searched for in PubMed, EMBASE, MEDLINE, Google Scholar, and Cochrane Library (Wiley) databases. The most common cannabinoid quantification techniques include gas chromatography (GC) and high-performance liquid chromatography (HPLC). Gas chromatography is often used in conjunction with mass spectrometry (MS) or flame ionization detection (FID).(Full article...)

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