Journal:Methods for quantification of cannabinoids: A narrative review
| Full article title | Methods for quantification of cannabinoids: A narrative review |
|---|---|
| Journal | Journal of Cannabis Research |
| Author(s) | Lazarjani, Masoumeh P.; Torres, Stephanie; Hooker, Thom; Fowlie, Chris; Young, Owen; Seyfoddin, Ali |
| Author affiliation(s) | Auckland University of Technology, Chapman University, ZeaCann Limited, |
| Primary contact | Email: Online form |
| Year published | 2020 |
| Volume and issue | 2 |
| Article # | 35 |
| DOI | 10.1186/s42238-020-00040-2 |
| ISSN | 2522-5782 |
| Distribution license | Creative Commons Attribution 4.0 International |
| Website | https://jcannabisresearch.biomedcentral.com/articles/10.1186/s42238-020-00040-2 |
| Download | https://jcannabisresearch.biomedcentral.com/track/pdf/10.1186/s42238-020-00040-2.pdf (PDF) |
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This article should be considered a work in progress and incomplete. Consider this article incomplete until this notice is removed. |
Abstract
Background: Around 144 cannabinoids have been identified in the Cannabis plant; among them tetrahydrocannabinol (THC) and cannabidiol (CBD) are the most prominent ones. Because of the legal restrictions on cannabis in many countries, it is difficult to obtain standards to use in research; nonetheless, it is important to develop a cannabinoid quantification technique, with practical pharmaceutical applications for quality control of future therapeutic cannabinoids.
Method: To find relevant articles for this narrative review paper, a combination of keywords such as "medicinal cannabis," "analytical," "quantification," and "cannabinoids" were searched for in PubMed, EMBASE, MEDLINE, Google Scholar, and Cochrane Library (Wiley) databases.
Results: The most common cannabinoid quantification techniques include gas chromatography (GC) and high-performance liquid chromatography (HPLC). Gas chromatography is often used in conjunction with mass spectrometry (MS) or flame ionization detection (FID). The major advantage of GC is with the quantification of terpenes. However, for evaluating acidic cannabinoids, it needs to be derivatized. The main advantage of HPLC is the ability to quantify both acidic and neutral forms of cannabinoids without derivatization, which is often accomplished with MS or ultraviolet (UV) detectors.
Conclusion: Based on the information presented in this review, the ideal cannabinoid quantification method is HPLC paired with tandem mass spectrometry (MS/MS).
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Notes
This presentation is faithful to the original, with only a few minor changes to presentation. Some grammar and punctuation was cleaned up to improve readability. In some cases important information was missing from the references, and that information was added.
