Journal:Beyond cannabinoids: Application of NMR-based metabolomics for the assessment of Cannabis sativa L. crop health

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Full article title Beyond cannabinoids: Application of NMR-based metabolomics for the assessment of Cannabis sativa L. crop health
Journal Frontiers in Plant Science
Author(s) Fernández, Santiago; Castro, Rossina; López-Radcenco, Andrés; Rodriguez, Paula; Carrera, Inés; García-Carnelli, Carlos; Moyna, Guillermo
Author affiliation(s) Universidad de la República - Montevideo, Universidad de la República - Paysandú
Primary contact Email: carlosga at fq dot edu dot uy
Editors Firoentino, Nunzio
Year published 2023
Volume and issue 14
Article # 1025932
DOI 10.3389/fpls.2023.1025932
ISSN 1664-462X
Distribution license Creative Commons Attribution 4.0 International
Website https://www.frontiersin.org/articles/10.3389/fpls.2023.1025932/full
Download https://www.frontiersin.org/articles/10.3389/fpls.2023.1025932/pdf (PDF)

Abstract

While Cannabis sativa L. varieties have been traditionally characterized by their major cannabinoid profile, it is now well established that other plant metabolites can also have physiological effects, including minor cannabinoids, terpenes, and flavonoids. Given the multiple applications of Cannabis in the medical field, it is therefore critical to characterize it according to its chemical composition (i.e., its metabolome) and not only its botanical traits. With this in mind, the cannabinoid and metabolomic profiles from inflorescences of two C. sativa varieties with either high Δ9-tetrahydrocannabinolic acid (THCA) or high cannabidiolic acid (CBDA) contents harvested at different times were studied. According to results from high-performance liquid chromatography (HPLC) and |NMR-based untargeted metabolomic analyses of organic and aqueous plant material extracts, we show that in addition to expected variations according to cannabinoid profiles, it is possible to distinguish between harvests of the same variety. In particular, it was possible to correlate variations in the metabolome with presence of powdery mildew, leading to the identification of molecular markers associated with this fungal infection in C. sativa.

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Notes

This presentation is faithful to the original, with only a few minor changes to presentation. Some grammar and punctuation was cleaned up to improve readability. In some cases important information was missing from the references, and that information was added. The original article lists references alphabetically, but this version—by design—lists them in order of appearance.