Hybrid mass spectrometer

From CannaQAWiki
Jump to navigationJump to search
The printable version is no longer supported and may have rendering errors. Please update your browser bookmarks and please use the default browser print function instead.

A hybrid mass spectrometer is a device for tandem mass spectrometry that consists of a combination of two or more m/z separation devices of different types.

Notation

Schematic of a quadrupole time-of-flight (QTOF) mass spectrometer.

The different m/z separation elements of a hybrid mass spectrometer can be represented by a shorthand notation. The symbol Q represents a quadrupole mass analyzer, q is a radio frequency collision quadrupole, TOF is a time-of-flight mass spectrometer, B is a magnetic sector and E is an electric sector.

Sector quadrupole

A sector instrument can be combined with a collision quadrupole and quadrupole mass analyzer to form a hybrid instrument.[1] A BEqQ configuration with a magnetic sector (B), electric sector (E), collision quadrupole (q) and m/z selection quadrupole (Q) have been constructed[2][3] and an instrument with two electric sectors (BEEQ) has been described.[4]

Quadrupole time-of-flight

Hybrid quadrupole time-of-flight mass spectrometer.

A triple quadrupole mass spectrometer with the final quadrupole replaced by a time-of-flight device is known as a quadrupole time-of-flight instrument.[5][6] Such an instrument can be represented as QqTOF.

Ion trap time-of-flight

In an ion trap instrument, ions are trapped in a quadrupole ion trap and then injected into the TOF. The trap can be 3-D[7] or a linear trap.[8]

Linear ion trap and Fourier transform mass analyzers

Hybrid linear ion trap Fourier transform ion cyclotron resonance mass spectrometer

A linear ion trap combined with a Fourier transform ion cyclotron resonance[9] or Orbitrap[10][11][12] mass spectrometer is marketed by Thermo Scientific as the LTQ FT and LTQ Orbitrap, respectively.

References

  1. ^ Glish, G.; McLuckey, S; Ridley, T; Cooks, R (1982). "A new "hybrid" sector/quadrupole mass spectrometer for mass spectrometry/mass spectrometry". International Journal of Mass Spectrometry and Ion Physics. 41 (3): 157–177. Bibcode:1982IJMSI..41..157G. doi:10.1016/0020-7381(82)85032-8.
  2. ^ Schoen, A.; Amy, J.W.; Ciupek, J.D.; Cooks, R.G.; Dobberstein, P.; Jung, G. (1985). "A hybrid BEQQ mass spectrometer". International Journal of Mass Spectrometry and Ion Processes. 65 (1–2): 125–140. Bibcode:1985IJMSI..65..125S. doi:10.1016/0168-1176(85)85059-X.
  3. ^ Harrison, A. (1986). "A hybrid BEQQ mass spectrometer for studies in gaseous ion chemistry". International Journal of Mass Spectrometry and Ion Processes. 74 (1): 13–31. Bibcode:1986IJMSI..74...13H. doi:10.1016/0168-1176(86)85020-0.
  4. ^ Winger, B. E.; Laue, H. -J.; Horning, S. R.; Julian, R. K.; Lammert, S. A.; Riederer, D. E.; Cooks, R. G. (1992). "Hybrid BEEQ tandem mass spectrometer for the study of ion/surface collision processes". Review of Scientific Instruments. 63 (12): 5613. Bibcode:1992RScI...63.5613W. doi:10.1063/1.1143391.
  5. ^ Shevchenko A, Loboda A, Shevchenko A, Ens W, Standing KG (May 2000). "MALDI quadrupole time-of-flight mass spectrometry: a powerful tool for proteomic research". Anal. Chem. 72 (9): 2132–41. doi:10.1021/ac9913659. PMID 10815976.
  6. ^ Steen H, Küster B, Mann M (July 2001). "Quadrupole time-of-flight versus triple-quadrupole mass spectrometry for the determination of phosphopeptides by precursor ion scanning". J Mass Spectrom. 36 (7): 782–90. Bibcode:2001JMSp...36..782S. doi:10.1002/jms.174. PMID 11473401.
  7. ^ Fountain ST, Lee H, Lubman DM (May 1994). "Ion fragmentation activated by matrix-assisted laser desorption/ionization in an ion-trap/reflectron time-of-flight device". Rapid Commun. Mass Spectrom. 8 (5): 407–16. Bibcode:1994RCMS....8..407F. doi:10.1002/rcm.1290080514. PMID 7517726.
  8. ^ Campbell, J. M.; Collings, B. A.; Douglas, D. J. (1998). "A new linear ion trap time-of-flight system with tandem mass spectrometry capabilities". Rapid Communications in Mass Spectrometry. 12 (20): 1463–1474. doi:10.1002/(SICI)1097-0231(19981030)12:20<1463::AID-RCM357>3.0.CO;2-H.
  9. ^ Syka JE, Marto JA, Bai DL, et al. (2004). "Novel linear quadrupole ion trap/FT mass spectrometer: performance characterization and use in the comparative analysis of histone H3 post-translational modifications". J. Proteome Res. 3 (3): 621–6. doi:10.1021/pr0499794. PMID 15253445.
  10. ^ Makarov A, Denisov E, Kholomeev A, Balschun W, Lange O, Strupat K, Horning S (2006). "Performance evaluation of a hybrid linear ion trap/orbitrap mass spectrometer". Anal. Chem. 78 (7): 2113–20. doi:10.1021/ac0518811. PMID 16579588.
  11. ^ Olsen JV, de Godoy LM, Li G, et al. (December 2005). "Parts per million mass accuracy on an Orbitrap mass spectrometer via lock mass injection into a C-trap". Mol. Cell. Proteomics. 4 (12): 2010–21. doi:10.1074/mcp.T500030-MCP200. PMID 16249172.
  12. ^ Yates JR, Cociorva D, Liao L, Zabrouskov V (January 2006). "Performance of a linear ion trap-Orbitrap hybrid for peptide analysis". Anal. Chem. 78 (2): 493–500. doi:10.1021/ac0514624. PMID 16408932.

Notes

This article is a direct transclusion of the Wikipedia article and therefore may not meet the same editing standards as CannabisQAwiki.

Retrieved from "https://www.cannaqa.wiki/index.php?title=Hybrid_mass_spectrometer&oldid=18161"